Introducing a complete TMEM175 assay portfolio for Parkinson’s and CNS drug discovery

New Case Study: Introduction G protein–gated inwardly rectifying potassium (GIRK) channels strongly shape neuronal and cardiac excitability and, in the brain, mainly form Kir3.1/Kir3.2 heterotetramers

Explore how our CHO-K1 Kv11.1 (hERG) recombinant cell line was validated for use in Automated Patch Clamp (APC) electrophysiology using the SyncroPatch 384 from Nanion Technologies. This application note highlights high-throughput cardiac safety testing capabilities, pharmacological validation with known hERG inhibitors, and key electrophysiological properties.

Explore the potential of Voltage-gated sodium channels (NaVs) for treating various diseases using a new fluorescence-based assay. This post highlights a method for screening modulators targeting NaV1.5, vital for cardiac function and targeted by antiarrhythmic drugs.

Harnessing Brilliant Sodium and automated imaging, we pinpoint ouabain’s potency on Na⁺/K⁺-ATPase in HEK and CHO cell co-cultures, unveiling drug effects with precision.