Price range: $306.00 through $695.00
ION Lithium Green 1 AM (ILG-1 AM), is a membrane-permeable, lithium-sensitive fluorescent indicator that enables solution- and cell-based lithium detection. ILG-1 is a high affinity and highly selective lithium sensor for fluorescence-based, lithium quantitation, with the largest fluorescence intensity enhancement upon binding to lithium. It can also be used for sodium channel drug discovery, as lithium readily permeates open NaV1.X channels resulting in a robust and selective readout of sodium channel activity.
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| Variation | SKU | Price | Quantity | Action |
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Size: 3 x 50 ug
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2215G
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$306.00
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Size: 10 x 50 ug
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2215F
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$695.00
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Size: 1 x 500 ug
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2215C
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$695.00
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Excitation: 515 nm
Emission: 535 nm
Solubility: DMSO
Purity: > 90%
Filter Set: GFP, FITC, YFP
Storage: -20°C
Size: 1 x 500 ug, 10 x 50 ug, 3 x 50 ug
ION Lithium Green 1 AM (ILG-1 AM), is a membrane-permeable, lithium-sensitive fluorescent dye that enables solution- and cell-based lithium detection. Due to its high affinity and selectivity for lithium ions, ILG-1 enables rapid determination of lithium concentrations in a variety of samples compared to the other commercial lithium assays.Â
As a key component in our Brilliant Lithium Assay, ILG-1 AM is also compatible with intracellular lithium detection and can be used for functional NaV1.X channel screening where lithium is a surrogate ion for sodium. Lithium readily permeates open NaV1.X channels while bypassing many endogenous sodium-handling mechanisms, resulting in a robust and selective readout of channel activity. Upon depolarization or pharmacological activation of NaV1.X channels, lithium accumulates intracellularly producing a rapid, quantifiable fluorescence increase that reflects real time channel activity.
ILG-1 AM, in its active form, displays a robust fluorescence increase to lithium in solution (approximately 10-fold) with an approximate Kd of 422 µM.
ILG-1 AM, in its active form, displays high selectivity over other monovalent cations over comparable concentration ranges.Â
ILG-1 AM, in its active form, displays high selectivity for lithium when compared to physiologically relevant monovalent and divalent cations. With respect to divalent cations, ILG-1 appears to bind manganese exclusively, albeit not as well as its preferred lithium ion.Â
