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A recombinant cell line that stably expresses human TMEM175 and provides a cell-based model to support discovery and profiling of TMEM175 potentiators and inhibitors.
Check out our validated assay formats for this target: Thallium-free GIRK Potassium Channel Assay, Brilliant Thallium Assay, Brilliant Thallium Snapshot Assay.
Size: 2 x 10^6M cells
Cells/vial: 2 x 10^6
Mycoplasma test: Pass
Species: Human
Guaranteed performance: > 10 passages
TMEM175 is a lysosomal ion channel that acts as both a proton and potassium channel, playing a crucial role in maintaining lysosomal pH. It is essential for lysosomal function and is linked to the risk of developing Parkinson’s disease, as mutations in TMEM175 can lead to impaired lysosomal degradation and increased neuronal susceptibility to alpha-synuclein aggregation.Â
This product is a cell-based, fluorescence-compatible model with stable expression in HEK293T cells, supporting FLIPR, Panoptic and Flextation workflows in the therapeutic area of Parkinson’s disease.
