SMCT2 Assay(s)

Background Information

Na⁺-coupled monocarboxylate cotransporter expressed in the renal proximal tubule and intestine. Handles renal reabsorption of short-chain fatty acids (lactate, pyruvate, butyrate, nicotinate) and other monocarboxylates. Emerging interest as a gut microbiome metabolite transporter with potential relevance to colonic homeostasis.

Family: SLC Transporter
Protein Name: SMCT2
Gene Name: SLC5A12

Organism : Human
Therapeutic Area: Renal

Assay Information

Validated Assay(s): Sodium-dependent SLC Transporter Assay
Assay type: Cell-based
Method: Fluorescence

Instrumentation: Panoptic
Plate Format: 384-well
Expression: Stable
Cell type: HEK293T

Testing Information

Functional Mode(s): Sustrate Uptake
Reference compound(s): Pyruvate

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