The norepinephrine transporter (NET), encoded by the SLC6A2 gene, is a sodium- and chloride-dependent symporter responsible for the reuptake of norepinephrine from the synaptic cleft into presynaptic neurons. By tightly controlling extracellular norepinephrine levels, NET plays a key role in modulating noradrenergic signaling in both the central and peripheral nervous systems, particularly in brain regions such as the locus coeruleus, hippocampus, and prefrontal cortex. Dysregulation of NET function has been implicated in various neuropsychiatric and cardiovascular disorders, including depression, anxiety, attention-deficit/hyperactivity disorder (ADHD), orthostatic intolerance, and postural tachycardia syndrome.