The GABA transporter 1 (GAT1), encoded by the SLC6A1 gene, is a sodium- and chloride-dependent symporter responsible for the high-affinity reuptake of γ-aminobutyric acid (GABA) from the synaptic cleft into presynaptic neurons and surrounding glial cells. By regulating extracellular GABA concentrations, GAT1 plays a key role in maintaining inhibitory tone and synaptic homeostasis throughout the central nervous system, particularly in regions such as the hippocampus, cortex, and cerebellum. Dysregulation of GAT1 function has been implicated in a variety of neurological and psychiatric disorders, including epilepsy, autism spectrum disorder, anxiety, and schizophrenia.