EAAT3 Assay(s)

Background Information

Neuronal Na⁺-coupled glutamate transporter expressed in excitatory neurons, kidney, and intestine. Genome-wide association studies link SLC1A1 to OCD via cortico-striatal glutamate circuit dysfunction — one of the best-supported glutamatergic GWAS hits in neuropsychiatry. LoF mutations cause dicarboxylic aminoaciduria.

Family: SLC Transporter
Protein Name: EAAT3
Gene Name: SLC1A1

Organism : Human
Therapeutic Area: Neurodegeneration, Neuropsychiatry, Rare-disease

Assay Information

Validated Assay(s): Sodium-dependent SLC Transporter Assay, Intracellular pH Assay
Assay type: Cell-based
Method: Fluorescence

Instrumentation: Panoptic
Plate Format: 384-well
Expression: Stable
Cell type: HEK293T

Testing Information

Functional Mode(s): Sustrate Uptake, Inhibitor
Reference compound(s): L-glutamate

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