TRPML1 Assay(s)

Background Information

TRPML1 (Transient Receptor Potential Mucolipin 1) is a non-selective, Ca²⁺-permeable cation channel located primarily in lysosomes. It is essential for trafficking, autophagy, and lipid metabolism, and is genetically linked to lysosmal storage disorders and Alzheimer's disease.

Family: Ion Channel
Protein Name: TRPML1
Gene Name: MCOLN1

Organism : Human
Therapeutic Area: Neurodegeneration, cancer

Assay Information

Validated Assay(s): Calcium flux
Assay type: Cell-based
Method: Fluorescence

Instrumentation: FLIPR, Panoptic, Flexstation
Plate Format: 96- or 384-well
Expression: Stable
Cell type: HEK293T

Testing Information

Functional Mode(s): Potentiator
Reference compound(s): MLSA-1

ose response curve for a Nav1.3 inhibitor assay using Brilliant Sodium 2 and the inhibitor, tetracaine.

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