Nav1.7 Assay(s)

Background Information

The Nav1.7 sodium channel, encoded by the SCN9A gene, is a voltage-gated channel found primarily in pain-sensing neurons. It's a genetically validated target for pain sensing, as loss of function mutations lead to complete pain insensitivity, making it a primary target for developing non-opioid pain therapeutics.

Family: Ion Channel
Protein Name: Nav1.7
Gene Name:SCNA9

Organism : Human
Therapeutic Area: Pain

Assay Information

Validated Assay(s):Brilliant Sodium 2, Brilliant Lithium Assay, Membrane Potential Assay
Assay type: Cell-based
Method: Fluorescence

Instrumentation: FLIPR, Panoptic, Flexstation
Plate Format: 96- or 384-well
Expression: Stable
Cell type: HEK293T

Testing Information

Functional Mode(s):Potentiator, Inhibitor
Reference compound(s): Tetracaine

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