Kv7.2 / Kv7.3 Assay(s)

Background Information

Encode the neuronal M-current, a slow non-inactivating K⁺ current that stabilizes resting membrane potential and raises the threshold for action potential firing. LoF mutations cause KCNQ2-related neonatal epileptic encephalopathy (NEE). M-current activators (Kv7 openers) modulate both seizure threshold and pain sensitization, establishing this as a pleiotropic CNS drug target.

Family: Ion Channel
Protein Name: Kv7.2/7.3
Gene Name: KCNQ2/3

Organism : Human
Therapeutic Area: Pain, Epilepsy, Neuropsychiatry, Rare-disease

Assay Information

Validated Assay(s): Thallium-free Potassium Channel Assay, Thallium Assay
Assay type: Cell-based
Method: Fluorescence

Instrumentation: Panoptic
Plate Format: 384-well
Expression: Stable
Cell type: HEK293T

Testing Information

Functional Mode(s): Activator, Inhibitor
Reference compound(s): XEN1101

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