Kv1.3 Assay(s)

Background Information

Kv1.3 is a voltage-gated potassium channel that plays a critical role in the immune system. It regulates T-cell activation by maintaining membrane potential, making it a key target for treating autoimmune diseases. It is also implicated in other conditions, such as cancer and metabolic disorders.

Family: Ion Channel
Protein Name: Kv1.3
Gene Name: KCNA3

Organism : Human
Therapeutic Area: Immunology, Cancer, CNS

Assay Information

Validated Assay(s): Thallium-free GIRK Potassium Channel Assay, Brilliant Thallium Assay
Assay type: Cell-based
Method: Fluorescence

Instrumentation: FLIPR, Panoptic, Flexstation
Plate Format: 96- or 384-well
Expression: Stable
Cell type: HEK293T

Testing Information

Functional Mode(s): Inhibitor
Reference compound(s): Dalazatide

Dose response curve for a Kv1.3 channel inhibition assay using a thallium-free potassium channel assay and the inhibitor, dalazatide.

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