GABA-A α2β3γ2 Assay(s)

Background Information

Most abundant synaptic GABA-A receptor subtype in the CNS; principal molecular target of benzodiazepines, Z-drugs, and neuroactive steroids. The α2 subunit mediates anxiolysis with reduced sedation relative to α1; γ2 subunit controls synaptic clustering and channel kinetics. GABRB3 mutations cause Dravet-like epileptic encephalopathy; GABRG2 mutations cause genetic epilepsy with febrile seizures plus (GEFS+).

Family: Ion Channel
Protein Name: GABA-A α2β3γ2
Gene Name: GABRA2, GABRB3, GABRG2

Organism : Human
Therapeutic Area: Epilepsy, Neuropsychiatry

Assay Information

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Testing Information

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