GABA-A receptor subtype containing α2, β3, and γ1 subunits. γ1-containing receptors have substantially reduced benzodiazepine sensitivity relative to γ2-containing counterparts and are enriched in amygdala and limbic regions. α2 subunit mediates the anxiolytic component of GABA-A modulation; α2-selective PAMs are in clinical development to achieve anxiolysis with reduced sedation liability. GABRG1 variants are associated with alcohol use disorder susceptibility.