SST2 Assay(s)

Background Information

Gi-coupled somatostatin receptor expressed at high levels in neuroendocrine tumors (NETs) and the pituitary. Primary therapeutic target for acromegaly (GH excess), gastrinoma, and GEP-NETs. Lu-DOTATATE (Lutathera) is a radiolabeled somatostatin analog that selectively delivers radiation to SST2-expressing tumor cells.

Family: GPCR
Protein Name: SST2 Receptor
Gene Name: SSTR2

Organism: Human
Therapeutic Area: Metabolic, Oncology

Assay Information

Validated Assay(s): cAMP, Calcium Assay
Assay type: Cell-based
Method: Fluorescence

Instrumentation: FLIPR, Panoptic
Plate Format: 384-well
Expression: Transient
Cell type: HEK293T

Testing Information

Functional Mode(s): Agonist
Reference compound(s): SST14

SST14 concentration-response data for the human SST2 receptor using cAMP and calcium fluorescence assays in HEK293T cells.
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