MC1R Assay(s)

Background Information

MC1R (Melanocortin 1 receptor) is a G-protein-coupled receptor (GPCR) found in melanocytes that controls skin and hair color by regulating melanin production. It's function is crucial for tanning and UV protection, making it a therapeutic target for pigmentation disorders and skin cancer, such as melanoma.

Family: GPCR
Protein Name: Melanocortin 1 Receptor
Gene Name: MC1R

Organism: Human
Therapeutic Area: Cancer

Assay Information

Validated Assay(s): cAMP, Ga15/16
Assay type: Cell-based
Method: Fluorescence

Instrumentation: FLIPR, Panoptic, Flexstation
Plate Format: 96- or 384-well
Expression: Transient
Cell type: HEK293T

Testing Information

Functional Mode(s): Agonist, Antagonist, Allosteric modulators
Reference compound(s): Setmelanotide

Setmelanotide concentration-response curve for the human MC1R receptor using a cAMP fluorescence assay in HEK293T cells.
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