M4 Receptor Assay(s)

Background Information

Gi-coupled muscarinic receptor with presynaptic modulation of dopamine release in striatum. Relevant to schizophrenia (dopamine dysregulation), Parkinson"s psychosis, and cognitive disorders. Component of the xanomeline mechanism in KarXT. M4 positive allosteric modulators (PAMs) are an emerging antipsychotic strategy.

Family: GPCR
Protein Name: M4 Receptor
Gene Name: CHRM4

Organism: Human
Therapeutic Area: Neuropsychiatry, Neurodegeneration

Assay Information

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Testing Information

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