LPAR1 Assay(s)

Background Information

High-affinity G protein-coupled receptor for lysophosphatidic acid (LPA), coupling to Gi, G12/13, and Gq to regulate cell proliferation, survival, migration, and cytoskeletal remodeling. Central mediator of fibroblast activation, vascular permeability, and aberrant fibroproliferative remodeling in idiopathic pulmonary fibrosis (IPF) and systemic sclerosis. LPAR1 antagonism suppresses collagen deposition and progressive fibrotic tissue destruction.

Family: GPCR
Protein Name: LPAR1
Gene Name: DRD1

Organism: Human
Therapeutic Area: Respiratory, Oncology, Rare-disease

Assay Information

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Testing Information

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