GLP-1R Assay(s)

Background Information

GLP-1R (Glucagon-Like Peptide-1 Receptor) is a G protein-coupled receptor (GPCR) that binds GLP-1. It's activity is key for regulating blood sugar, appetite, and metabolism by boosting insulin release and slowing digestion, making it a key target for diabetes and weight loss drugs.

Family: GPCR
Protein Name: Glucagon-Like Peptide-1 Receptor
Gene Name: GLP-1R

Organism : Human
Therapeutic Area: Metabolism

Assay Information

Validated Assay(s):cAMP, Calcium flux, Ga15/16
Assay type: Cell-based
Method: Fluorescence

Instrumentation: FLIPR, Panoptic, Flexstation
Plate Format: 96- or 384-well
Expression: Transient
Cell type: HEK293T

Testing Information

Functional Mode(s): Agonist, Antagonist, Allosteric modulators
Reference compound(s): Setmelanotide

Enquire now