D5 Dopamine Receptor Assay(s)

Background Information

The D5 dopamine receptor (DRD5) is a G-protein coupled receptor (GPCR) that is crucial for memory, learning, and cognition. Highly sensitive to dopamine, it plays key roles in reward systems and potential neuropsychiatric disorders.

Family: GPCR
Protein Name: D5 Dopamine Receptor
Gene Name: DRD5

Organism : Human
Therapeutic Area: CNS, Addiction

Assay Information

Validated Assay(s):cAMP, Ga15/16
Assay type: Cell-based
Method: Fluorescence

Instrumentation: FLIPR, Panoptic, Flexstation
Plate Format: 96- or 384-well
Expression: Transient
Cell type: HEK293T

Testing Information

Functional Mode(s): Agonist, Antagonist, Allosteric modulators
Reference compound(s): Dopamine

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