D1 Dopamine Receptor Assay(s)

Background Information

The D1 dopamine receptor (DRD1), is the most abundant, rhodopsin-like G protein-coupled receptor (GPCR) in the brain, primarily signaling through Gs to stimulate adenylate cyclase and increase cAMP. It plays a critical role in cognitive processes, motivation, and reward-based learning. 

Family: GPCR
Protein Name: D1 Dopamine Receptor
Gene Name: DRD1

Organism : Human
Therapeutic Area: CNS, Addiction, Neurodegeneration

Assay Information

Validated Assay(s):cAMP, Ga15/16
Assay type: Cell-based
Method: Fluorescence

Instrumentation: FLIPR, Panoptic, Flexstation
Plate Format: 96- or 384-well
Expression: Transient
Cell type: HEK293T

Testing Information

Functional Mode(s): Agonist, Antagonist, Allosteric modulators
Reference compound(s): Dopamine

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