CCR5 Assay(s)

Background Information

Gi-coupled chemokine receptor predominantly expressed on T cells, macrophages, and dendritic cells. Serves as the principal coreceptor for macrophage-tropic (R5) strains of HIV-1 entry into host immune cells. CCR5 antagonism provides potent viral entry inhibition without broad immunosuppression. Also under therapeutic evaluation in inflammatory diseases, non-alcoholic steatohepatitis (NASH/MASH), and solid tumor microenvironments (modulating regulatory T-cell and myeloid-derived suppressor cell trafficking).

Family: GPCR
Protein Name: CCR5
Gene Name: CCR5

Organism: Human
Therapeutic Area: Immunology, Oncology

Assay Information

Validated Assay(s): Calcium Assay
Assay type: Cell-based
Method: Fluorescence

Instrumentation: FLIPR
Plate Format: 384-well
Expression: Transient
Cell type: HEK293T

Testing Information

Functional Mode(s): Agonist, Antagonist
Reference compound(s): CCL4