CCK1 Assay(s)

Background Information

Gq-coupled cholecystokinin receptor expressed on vagal afferents, duodenum, and gallbladder. Mediates gut-brain satiety signaling (post-meal CCK release inhibits feeding), gallbladder contraction, and pancreatic enzyme secretion. Key target in appetite regulation research and GI physiology.

Family: GPCR
Protein Name: CCK1 Receptor
Gene Name: CCKAR

Organism: Human
Therapeutic Area: Metabolic

Assay Information

Validated Assay(s): cAMP, Calcium Assay
Assay type: Cell-based
Method: Fluorescence

Instrumentation: FLIPR
Plate Format: 384-well
Expression: Transient
Cell type: HEK293T

Testing Information

Functional Mode(s): Agonist, Antagonist
Reference compound(s): CCK-8

CCK-8 concentration-response curve for the human CCK1 receptor in a Brilliant Calcium fluorescence assay using HEK293T cells.
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