CB1 Assay(s)

Background Information

Gi-coupled endocannabinoid receptor mediating spinal and supraspinal pain modulation, appetite, anxiety, and reward. The primary molecular target of THC and the mechanistic basis of cannabis analgesia. CB1 inverse agonists showed cardiovascular and metabolic benefits but were withdrawn for psychiatric adverse effects (suicidal ideation).

Family: GPCR
Protein Name: CB1
Gene Name: CNR1

Organism: Human
Therapeutic Area: Pain, Neuropsychiatry

Assay Information

Validated Assay(s): cAMP
Assay type: Cell-based
Method: Fluorescence

Instrumentation: Panoptic
Plate Format: 384-well
Expression: Transient
Cell type: HEK293T

Testing Information

Functional Mode(s): Agonist
Reference compound(s): CP-55940

CP-55940 concentration-response curve for the human CB1 receptor in a Gαi/o cADDis cAMP fluorescence assay using HEK293T cells.
Enquire now