Complex Protocols

On-instrument liquid handling enables advanced experimental workflows

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Our advanced instrumentation handles complex experimental workflows with ease to help you answer important questions related to your biology and move faster towards your next discovery.

  • Kinetic compound profiling: Monitor responses in real-time to gain deeper insights into SAR.
  • Multiple addition protocols: Sequential additions for antagonist and inhibition mode assays.
  • Multiple readouts: Multiple lasers and filters enable multiplexed, FRET, and ratiometric readouts.
  • Washout assays: Determine off-rates with complete solution exchange and column-by-column additions.
  • Optogenetics: Ultra-fast laser switching can trigger your desired response.

Kinetic compound profiling

Move away from endpoint assays to reveal your compound activity in real-time with live-cell sensors, on instrument compound additions, and continuous kinetic readouts from minutes to hours.

Combined with comprehensive analytics to improve assay performance and distinguish between lead candidates.

Multiple addition protocols

Having an Agilent Bravo on instrument provides enough room for 3 tip boxes, 3 compound plates, and a couple of extra bays to spare, enabling numerous sequential compound additions without ever pausing your data acquisition. This feature is most commonly used for antagonists and inhibition mode assays, as well as exploring multi-step depolarizations of voltage-gated ion channels.

Multiple readouts

Transform your drug discovery with state-of-the-art optics. Equipped with 6 lasers and 4 emission filters, the Panoptic is uniquely designed for the most advanced readouts.

  • Discrete laser-based illumination minimizes spectral overlap.
  • Coverage of the full visible spectrum with adjustable emission filters.
  • Dual channel acquisition for FRET, multiplexed, and ratiometric readouts.

Washout assays

We specialize in tailoring complex protocols that unveil on/off binding kinetics of small molecules and biologics. With column-by-column additions at user defined timepoints, you can determine how long your compound needs to alter protein function or how long it remains active after solution exchange.

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