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SPECIFICATIONS
PRODUCT DESCRIPTION
DOCUMENTATION
REFERENCES

Thallos AM

$495.00

Best in class, green fluorescent, thallium (Tl⁺) indicator, membrane permeable. Works with potassium (K⁺), sodium (Na⁺), and monovalent cation channels, and transporters.

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SPECIFICATIONS

Excitation:

490 nm 

Emission:

515 nm 

MW:

840

Solubility:

DMSO
Product code: 10 x 50ug: 1381F/ 500ug: 1381C

product description
Thallos is a green fluorescent, intracellular thallium (Tl⁺) indicator, and has been the gold standard for fluorescence-based potassium (K⁺) channel HTS for nearly 2 decades. Thallos also delivers outstanding results for a wide variety of monovalent cation (sodium – Na⁺) channels, transporters, and GPCRs.
Fluorescence profile of voltage gated sodium channel (Nav1.3) activation using veratridine with corresponding concentration response curve. Data acquired using Thallos AM.
Fluorescence profile of voltage gated sodium channel (Nav1.3) inhibition using tetracaine with corresponding concentration response curve. Data acquired using Thallos AM

documentation

References

Weaver CD, Harden D, Dworetzky SI, Robertson B, Knox RJ. A thallium-sensitive, fluorescence-based assay for detecting and characterizing potassium channel modulators in mammalian cells. J Biomol Screen. 2004 Dec;9(8):671-7. doi: 10.1177/1087057104268749


Weaver CD. Thallium Flux Assay for Measuring the Activity of Monovalent Cation Channels and Transporters. Methods Mol Biol. 2018;1684:105-114. doi: 10.1007/978-1-4939-7362-0_9

Carmosino M, Rizzo F, Torretta S, Procino G, Svelto M. High-throughput fluorescent-based NKCC functional assay in adherent epithelial cells. BMC Cell Biol. 2013 Mar 18;14:16. doi: 10.1186/1471-2121-14-16

Du Y, Days E, Romaine I, Abney KK, Kaufmann K, Sulikowski G, Stauffer S, Lindsley CW, Weaver CD. Development and validation of a thallium flux-based functional assay for the sodium channel NaV1.7 and its utility for lead discovery and compound profiling. ACS Chem Neurosci. 2015 Jun 17;6(6):871-8. doi: 10.1021/acschemneuro.5b0000

Zhang D, Gopalakrishnan SM, Freiberg G, Surowy CS. A thallium transport FLIPR-based assay for the identification of KCC2-positive modulators. J Biomol Screen. 2010 Feb;15(2):177-84. doi: 10.1177/1087057109355708

Niswender CM, Johnson KA, Luo Q, Ayala JE, Kim C, Conn PJ, Weaver CD. A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors. Mol Pharmacol. 2008 Apr;73(4):1213-24. doi: 10.1124/mol.107.041053

Delpire E, Days E, Lewis LM, Mi D, Kim K, Lindsley CW, Weaver CD. Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5383-8. doi: 10.1073/pnas.0812756106

 

Schmalhofer WA, Swensen AM, Thomas BS, Felix JP, Haedo RJ, Solly K, Kiss L, Kaczorowski GJ, Garcia ML. A pharmacologically validated, high-capacity, functional thallium flux assay for the human Ether-à-go-go related gene potassium channel. Assay Drug Dev Technol. 2010 Dec;8(6):714-26. doi: 10.1089/adt.2010.0351

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