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Thallos AM

$242.00 – $545.00

Best in class, green fluorescent, thallium (Tl⁺) indicator, membrane permeable. Works with potassium (K⁺), sodium (Na⁺), and monovalent cation channels, and transporters.

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Variation SKU Price Quantity Action
Size: 3 x 50 ug
1381G
$242.00
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Size: 10 x 50 ug
1381F
$545.00
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Size: 500 ug
1381C
$545.00
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Thallos AM product packaging with thallium (Tl+) ion sticker, dark background
Thallos AM (thallium indicator) excitation and emission spectra
Thallos AM product packaging with thallium (Tl+) ion sticker, transparent background
SKU: 1381 Categories: , Synonyms: , , , , ,

Specifications

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Product Description

Thallos AM promo bannerThallos is a green fluorescent, intracellular thallium (Tl⁺) indicator, and has been the gold standard for fluorescence-based potassium (K⁺) channel HTS for nearly 2 decades. Thallos also delivers outstanding results for a wide variety of monovalent cation (sodium – Na⁺) channels, transporters, and GPCRs.Potassium and sodium channel assays using thallium flux
Fluorescence profile of voltage gated sodium channel (Nav1.3) activation using veratridine with corresponding concentration response curve. Data acquired using a FLIPR-compatible Brilliant Thallium Assay kit
Fluorescence profile of voltage gated sodium channel (Nav1.3) inhibition using tetracaine with corresponding concentration response curve. Data acquired using a FLIPR-compatible Brilliant Thallium Assay kit
Brilliant thallium flux assay used for voltage-gated potassium channels. Data show fluorescence kinetic profiles and corresponding dose response curve of hERG channel inhibition.
Brilliant thallium flux assay used for voltage-gated potassium channels. Data show fluorescence kinetic profiles and corresponding dose response curve of KCNQ inhibition.
Brilliant thallium flux assay used for inward-rectifying potassium channels. Data show fluorescence kinetic profiles and corresponding dose response curve of GIRK activation.
Thalos-AM_Monovalent_Divalent-v2

References

Weaver CD, Harden D, Dworetzky SI, Robertson B, Knox RJ. A thallium-sensitive, fluorescence-based assay for detecting and characterizing potassium channel modulators in mammalian cells. J Biomol Screen. 2004 Dec;9(8):671-7. doi: 10.1177/1087057104268749
Weaver CD. Thallium Flux Assay for Measuring the Activity of Monovalent Cation Channels and Transporters. Methods Mol Biol. 2018;1684:105-114. doi: 10.1007/978-1-4939-7362-0_9
Carmosino M, Rizzo F, Torretta S, Procino G, Svelto M. High-throughput fluorescent-based NKCC functional assay in adherent epithelial cells. BMC Cell Biol. 2013 Mar 18;14:16. doi: 10.1186/1471-2121-14-16
Du Y, Days E, Romaine I, Abney KK, Kaufmann K, Sulikowski G, Stauffer S, Lindsley CW, Weaver CD. Development and validation of a thallium flux-based functional assay for the sodium channel NaV1.7 and its utility for lead discovery and compound profiling. ACS Chem Neurosci. 2015 Jun 17;6(6):871-8. doi: 10.1021/acschemneuro.5b0000
Zhang D, Gopalakrishnan SM, Freiberg G, Surowy CS. A thallium transport FLIPR-based assay for the identification of KCC2-positive modulators. J Biomol Screen. 2010 Feb;15(2):177-84. doi: 10.1177/1087057109355708
Niswender CM, Johnson KA, Luo Q, Ayala JE, Kim C, Conn PJ, Weaver CD. A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors. Mol Pharmacol. 2008 Apr;73(4):1213-24. doi: 10.1124/mol.107.041053
Delpire E, Days E, Lewis LM, Mi D, Kim K, Lindsley CW, Weaver CD. Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5383-8. doi: 10.1073/pnas.0812756106
Schmalhofer WA, Swensen AM, Thomas BS, Felix JP, Haedo RJ, Solly K, Kiss L, Kaczorowski GJ, Garcia ML. A pharmacologically validated, high-capacity, functional thallium flux assay for the human Ether-à-go-go related gene potassium channel. Assay Drug Dev Technol. 2010 Dec;8(6):714-26. doi: 10.1089/adt.2010.0351
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