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SPECIFICATIONS
PRODUCT DESCRIPTION
DOCUMENTATION
REFERENCES

Thallos AM product packaging with thallium (Tl+) ion sticker, dark background

Thallos AM (thallium indicator) excitation and emission spectra

Thallos AM

$242.00 – $545.00

Best in class, green fluorescent, thallium (Tl⁺) indicator, membrane permeable. Works with potassium (K⁺), sodium (Na⁺), and monovalent cation channels, and transporters.

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SPECIFICATIONS

Excitation:

490 nm

Emission:

515 nm

MW:

840 g/mol

Solubility:

DMSO

Product code: 10 x 50ug: 1381F/ 500ug: 1381C

product description

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Thallos is a green fluorescent, intracellular thallium (Tl⁺) indicator, and has been the gold standard for fluorescence-based potassium (K⁺) channel HTS for nearly 2 decades. Thallos also delivers outstanding results for a wide variety of monovalent cation (sodium – Na⁺) channels, transporters, and GPCRs.

Potassium and sodium channel assays using thallium flux

Brilliant thallium flux assay used for voltage-gated potassium channels. Data show fluorescence kinetic profiles and corresponding dose response curve of hERG channel inhibition.

Brilliant thallium flux assay used for voltage-gated potassium channels. Data show fluorescence kinetic profiles and corresponding dose response curve of KCNQ inhibition.

Brilliant thallium flux assay used for inward-rectifying potassium channels. Data show fluorescence kinetic profiles and corresponding dose response curve of GIRK activation.

documentation

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References

Weaver CD, Harden D, Dworetzky SI, Robertson B, Knox RJ. A thallium-sensitive, fluorescence-based assay for detecting and characterizing potassium channel modulators in mammalian cells. J Biomol Screen. 2004 Dec;9(8):671-7. doi: 10.1177/1087057104268749

Weaver CD. Thallium Flux Assay for Measuring the Activity of Monovalent Cation Channels and Transporters. Methods Mol Biol. 2018;1684:105-114. doi: 10.1007/978-1-4939-7362-0_9

Carmosino M, Rizzo F, Torretta S, Procino G, Svelto M. High-throughput fluorescent-based NKCC functional assay in adherent epithelial cells. BMC Cell Biol. 2013 Mar 18;14:16. doi: 10.1186/1471-2121-14-16

Du Y, Days E, Romaine I, Abney KK, Kaufmann K, Sulikowski G, Stauffer S, Lindsley CW, Weaver CD. Development and validation of a thallium flux-based functional assay for the sodium channel NaV1.7 and its utility for lead discovery and compound profiling. ACS Chem Neurosci. 2015 Jun 17;6(6):871-8. doi: 10.1021/acschemneuro.5b0000

Zhang D, Gopalakrishnan SM, Freiberg G, Surowy CS. A thallium transport FLIPR-based assay for the identification of KCC2-positive modulators. J Biomol Screen. 2010 Feb;15(2):177-84. doi: 10.1177/1087057109355708

Niswender CM, Johnson KA, Luo Q, Ayala JE, Kim C, Conn PJ, Weaver CD. A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors. Mol Pharmacol. 2008 Apr;73(4):1213-24. doi: 10.1124/mol.107.041053

Delpire E, Days E, Lewis LM, Mi D, Kim K, Lindsley CW, Weaver CD. Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5383-8. doi: 10.1073/pnas.0812756106

Schmalhofer WA, Swensen AM, Thomas BS, Felix JP, Haedo RJ, Solly K, Kiss L, Kaczorowski GJ, Garcia ML. A pharmacologically validated, high-capacity, functional thallium flux assay for the human Ether-à-go-go related gene potassium channel. Assay Drug Dev Technol. 2010 Dec;8(6):714-26. doi: 10.1089/adt.2010.0351

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