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SPECIFICATIONS
PRODUCT DESCRIPTION
DOCUMENTATION
REFERENCES

IPG-4 AM potassium indicator packaging

IPG-4 potassium indicator packaging, transparent background

IPG-4 AM

$173.00 – $391.00

Yellow-green fluorescent, potassium indicator, membrane permeable. Higher potassium affinity than IPG-1 and IPG-2, with improved selectivity for potassium over sodium.

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SPECIFICATIONS

Excitation:

525 nm

Emission:

545 nm

Kd:

7 mM

MW:

1333

Solubility:

DMSO

Synonyms: Asante Potassium Green, Ion Potassium Green, APG, IPG, APG-4, IPG-4

Product code: 10 x 50ug: 3021F/ 500ug: 3021C

product description

ION Potassium Green – 4 (IPG-4) is a yellow-green fluorescent, potassium (K⁺) indicator with Ex/Em: 525 nm/545 nm and a high-selectivity for potassium over other monovalent cations. IPG-4 has the highest affinity (Kd = 7 mM) among IPG analogues – IPG-2 (Kd = 18 mM) and IPG-1 (Kd = 50 mM), and is useful for measuring changes in intracellular or extracellular potassium concentrations.

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IPG-4, a potassium indicator, fluorescence spectra

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GIRK channel (Kir3.1/3.2) activator dose response curve comparison with data acquired using IPG-4 AM on a plate reader and microscope. Inset shows a dose response curve generated using thallium flux.

Fluorescence data of IPG-4 potassium indicator response to potassium.

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Image analysis of IPG-4 assay used to identify activators of a GIRK potassium channel.

Fluorescence profiles and images of cells loaded with IPG-4 in the presence or absence of probenecid demonstrating IPG-4 is not a Pgp substrate, and can be used to conduct probenecid-free potassium channel assays.

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documentation

coa

References

Rana PS, Gibbons BA, Vereninov AA, Yurinskaya VE, Clements RJ, Model TA, Model MA. Calibration and characterization of intracellular Asante Potassium Green probes, APG-2 and APG-4. Anal Biochem. 2019 Feb 15;567:8-13. doi: 10.1016/j.ab.2018.11.024

Kilic K, Karatas H, Dönmez-Demir B, Eren-Kocak E, Gursoy-Ozdemir Y, Can A, Petit JM, Magistretti PJ, Dalkara T. Inadequate brain glycogen or sleep increases spreading depression susceptibility. Ann Neurol. 2018 Jan;83(1):61-73. doi: 10.1002/ana.25122

Wellbourne-Wood J, Rimmele TS, Chatton JY. Imaging extracellular potassium dynamics in brain tissue using a potassium-sensitive nanosensor. Neurophotonics. 2017 Jan;4(1):015002. doi: 10.1117/1.NPh.4.1.015002

Prindle, A., Liu, J., Asally, M. et al. Ion channels enable electrical communication in bacterial communities. Nature 527, 59–63 (2015). https://doi.org/10.1038/nature15709

Ong, S. T., Ng, A. S., Ng, X. R., Zhuang, Z., Wong, B. H. S., Prasannan, P., … & Chandy, K. G. (2019). Extracellular K+ dampens T cell functions: implications for immune suppression in the tumor microenvironment. Bioelectricity, 1(3), 169-179.

Humphries J, Xiong L, Liu J, Prindle A, Yuan F, Arjes HA, Tsimring L, Süel GM. Species-Independent Attraction to Biofilms through Electrical Signaling. Cell. 2017 Jan 12;168(1-2):200-209.e12. doi: 10.1016/j.cell.2016.12.014

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