Brilliant Thallium

Name: Brilliant Thallium | ION Biosciences
SKU: 11000
Availability: InStock

$211.00 – $3,597.00

A potassium channel assay, and so much more. ION’s high-throughput, no wash thallium (Tl⁺) flux assay is an optimal solution for measuring the activity of potassium (K⁺), sodium (Na⁺), and non-selective cation channels and their effectors including transporters and GPCRs.

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Variation	SKU	Price	Quantity	Action
Size: pIONeer Kit - 2 plates	11000-2	$211.00	Brilliant Thallium quantity	Add to cart
Size: Flex Kit - 10 plates	11000-10	$473.00	Brilliant Thallium quantity	Add to cart
Size: Express Kit - 100 plates	11000-100	$3,597.00	Brilliant Thallium quantity	Add to cart

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Thallium flux assay packaging, a potassium channel assay and more

Thallium flux assay example, showing fluorescence images of Thallos loaded cells before and after the addition of Thallium (Tl+)

XE-991 dihydrochloride is a potent and selective blocker of KV7 (KCNQ) voltage-gated potassium channels, as shown in this dose response curve generated using a thallium flux assay

Sample thallium flux data from a potassium channel assay, Kv7.2/7.3 (KCNQ), with XE-991, a potent inhibitor.

SKU: 11000 Categories: Ion Channels and Transporter Assays, Potassium, Sodium Synonyms: Brilliant Thallium Express, FLIPR Potassium Assay Kit, FluoOR Red Potassium Ion Channel Assay, Fluxor II Green Potassium Ion Channel Assay, FluxOR Potassium Assay, Fluxor Potassium Ion Channel Assay, Monovalent Channel Assay Kit, Potassium Channel Assay Kit, Screen Quest™ No Wash Potassium Channel Assay, Sodium Channel Assay Kit, Thallium Assay Kit, variable

Specifications

Excitation: 490 nm

Emission: 515 nm

MW: 840 g/mol

Filter Set: FITC, GFP

Storage: Various conditions

Product Description

ION Biosciences’ Brilliant Thallium (Tl⁺) Assay is a total assay solution for multi-well plate-based, high-throughput measurements of Tl⁺ flux through K⁺, Na⁺, non-selective cation channels, and some Na⁺ or K⁺ transporters. The ION Biosciences’ Brilliant Thallium Assay is also useful for a wide range of effectors of ion channels and transporters including G protein-coupled receptors, lipid and protein kinase, for example.

In multi-well, plate-based formats, the Brilliant Thallium Assay can be used to discover and characterize the effects of tens to many tens-of-thousands of compounds and environmental factors on effectors of Tl⁺ flux. Over the past 15 years, fluorescence-based measures of Tl⁺ flux have been widely utilized to discover small molecule modulators of a host of ion channels, transporters, GPCRS and other targets of interest for both drug discovery and basic research.

Our Flex kit provides all the necessary reagents in a format that maximizes flexibility for your assay design and optimization needs.

Our Express kit is custom tailored to customer’s needs, providing only the reagents you need in the amounts you need them. Less waste, higher reproducibility, and more convenience.

Data

How ION’s Brilliant Thallium Assay Outperforms the Competition

ION Biosciences Brilliant Thallium Assay excels in potassium channel assays, standing out among market leaders for its robust signal amplitude, high Z’, customizability, and cost-effectiveness.

Thallos AM outperforms ThermoFisher´s FluxOR dye in potassium channel assay

Higher Signal: 50% larger response
Better Z´: Clearly distinguish active from inactive compounds
Trusted by Industry: Validated by Large Pharmaceutical Company

Brilliant Thallium has a larger signal amplitude than FluxOR II Green

Greater sensitivity: Larger response means you can detect activity with confidence
Cost-Effective:Use less thallium per well, saving you more money for HTS campaigns

FLIPR Potassium Channel assay (left) vs. Brilliant Thallium (right)

Assay Quality: Comparable Z´values ensure reliable hit identification
Comparable Potencies: IC50 values match Molecular Devices´kit across multiple compounds
Flexibility: Brilliant Thallium offers flexibility to run wash and no wash formats in the same box

Examples of ion channel and transporter assays

ION Biosciences’ Brilliant Thallium Assay is more than just a potassium channel solution. It can also be used to uncover modulators of voltage-gated sodium channels, transporters like KCC, non-selective cation channels, and Gi/o GPCRs.

Brilliant thallium flux assay used for voltage-gated potassium channels. Data show fluorescence kinetic profiles and corresponding dose response curve of hERG channel inhibition.

Brilliant thallium flux assay used for inward-rectifying potassium channels. Data show fluorescence kinetic profiles and corresponding dose response curve of GIRK activation.

Experience Superior Performance

ION’s Brilliant Thallium Assay isn’t just another option—it’s a superior solution for potassium channel assays and more. With Thallos AM at its core, our kit outperforms industry leaders like ThermoFisher and has key advantages against Molecular Devices too. Offering enhanced signal amplitude, greater sensitivity, flexibility, and cost-effectiveness, Brilliant Thallium is designed to deliver reliable, high-quality data for your research.

Learn more

First time using thallium flux assays to measure ion channel activity? Read our step-by-step guide for how to turn raw kinetic traces into informative dose response curves.

Have a GFP-expressing ion channel, check out Brilliant Thallium Gold, our Brilliant Thallium Assay packaged with Thallos Gold, a red-shifted thallium indicator for projects demanding something other than a green dye.