SGLT1 Assay(s)

Background Information

High-affinity Na⁺/glucose cotransporter responsible for dietary glucose and galactose absorption in small intestinal enterocytes. Also contributes to late proximal tubule glucose reabsorption in kidney. SLC5A1 LoF mutations cause glucose-galactose malabsorption (GGM), a life-threatening neonatal diarrheal disease requiring immediate dietary intervention.

Family: SLC Transporter
Protein Name: SGLT1
Gene Name: SLC5A1

Organism : Human
Therapeutic Area: Metabolic, Renal, Rare-disease

Assay Information

Validated Assay(s): Sodium-dependent SLC Transporter Assay
Assay type: Cell-based
Method: Fluorescence

Instrumentation: Panoptic
Plate Format: 384-well
Expression: Stable
Cell type: HEK293T

Testing Information

Functional Mode(s): Sustrate Uptake, Inhibitor
Reference compound(s): AMG

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