MC3R Assay(s)

Background Information

The Melanocortin-3 Receptor (MC3R) is a G-protein coupled receptor, crucial for regulating energy homeostasis, appetite, and metabolism. It acts as a negative regulator of the melanocortin system, controlling AgRP neuron activity, fat storage, growth, puberty, and circadian rhythms, with mutations linked to obesity.

Family: GPCR
Protein Name: Melanocortin 3 Receptor
Gene Name: MC3R

Organism: Human
Therapeutic Area: Metabolism

Assay Information

Validated Assay(s): cAMP, Ga15/16
Assay type: Cell-based
Method: Fluorescence

Instrumentation: FLIPR, Panoptic, Flexstation
Plate Format: 96- or 384-well
Expression: Transient
Cell type: HEK293T

Testing Information

Functional Mode(s): Agonist, Antagonist, Allosteric modulators
Reference compound(s): Setmelanotide

Setmelanotide concentration-response curve for the human MC3R receptor using a cAMP fluorescence assay in HEK293T cells.
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