$895.00
ION’s Sodium-dependent SLC Transporter Assay detects SLC transporter activity of SLCs that co-transport sodium, such as the SLC6 transporter family. This assay is ideal for hit finding and lead optimization applications in drug discovery, and can be used to discover substrates, potentiators, and inhibitors of sodium-dependent SLC transporters.
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Excitation: 515 nm
Emission: 545 nm
Solubility: DMSO
Filter Set: GFP, FITC, YFP
Storage: Various conditions
ION Biosciences’ Sodium-dependent SLC Transporter Assay utilizes ION Natrium Green 2 (ING-2 AM), a sodium-sensitive fluorescent indicator, to detect solute carrier (SLC) transporter mediated sodium influx. This assay kit provides a highly-sensitive, robust, and high-throughput method to measure SLC transporter activity with benefits including:
Optimized for high-throughput screening in 96- and 384-well formats, ION’s Sodium-dependent SLC Transporter Assay kit ensures reliability and reproducibility, making it ideal for hit finding and lead optimization applications. Backed by ION’s exceptional technical support, this kit simplifies your research workflow by providing ready-to-use buffers and simple protocols designed by the experts you’ve learned to trust.
Measure substrate uptake in real-time as demonstrated in kinetic traces of various GABA concentrations to GAT1 (SLC6A1) expressing cells.
Validated uptake assays for multiple Sodium-dependent SLC transporters, including SLC6A1 and SLC6A9, among other targets.
The Sodium-dependent SLC assay can also be used to identify inhibitors of transporter function, as showcased in a 384-well assay for SLC6A9 (GlyT1), with IC50s comparable to reported literature values.
Achieve exceptional Z’ whether you use AUC or Vmax analysis, ensuring this kit is ready for your next SLC hit-finding campaign.
