Brilliant Thallium Gold

Name: Brilliant Thallium Gold | Potassium Channel Assay | ION Biosciences
SKU: 11020
Availability: InStock

Price range: $221.00 through $496.00

A potassium channel assay, and so much more. Brilliant Thallium Gold includes Thallos Gold – ION’s gold fluorescent (Ex/Em = 528/552 nm) thallium (Tl+) indicator. Red-shifted excitation and emission enable multiplexing with GFP-expressing cells or other green fluorescent indicators. Useful for fluorescence-based potassium (K+) channel assays and for studying a wide variety of monovalent cation channels (sodium channels), transporters, and GPCRs.

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Variation	SKU	Price	Quantity	Action
Size: pIONeer Kit - 2 plates	11020-2	$221.00	Brilliant Thallium Gold quantity	Add to cart
Size: Flex Kit - 10 plates	11020-10	$496.00	Brilliant Thallium Gold quantity	Add to cart

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Brilliant thallium gold product packaging. A thallium flux assay for potassium channels, sodium channels, and more

SKU: 11020 Categories: Ion Channels and Transporter Assays, Potassium, SLC Transporter Assay, Sodium Synonyms: Brilliant Thallium Gold, FLIPR Potassium Assay Kit, FluoOR Red Potassium Ion Channel Assay, Fluxor II Green Potassium Ion Channel Assay, FluxOR Potassium Assay, Fluxor Potassium Ion Channel Assay, Monovalent Channel Assay Kit, Potassium Channel Assay Kit, Screen Quest™ No Wash Potassium Channel Assay, Sodium Channel Assay Kit, Thallium Assay Kit, variable

Specifications

Excitation: 530 nm

Emission: 550 nm

MW: 826 g/mol

Filter Set: YFP

Storage: Various conditions

Size: Flex Kit - 10 plates, pIONeer Kit - 2 plates

Product Description

ON Biosciences Brilliant Thallium Gold Assay kit is a total assay solution for multi-well plate-based, high-throughput measurements of Tl+ flux through K+, Na+, non-selective cation channels, and some Na+ or K+ transporters. The kit includes our proprietary Thallos Gold indicator (Ex/Em: 530/546 nm), which is responsive to intracellular Tl+ dynamics. Thallos Gold’s spectral properties allow for multiplexing with GFP-expressing cells or other green-fluorescent indicators, and will help mitigate false positives caused by auto-fluorescent compounds within a library. The ION Biosciences Brilliant Thallium Gold Assay is also useful for a wide range of effectors of ion channels and transporters including G protein-coupled receptors, lipid kinases and protein kinases.

Red-shifted excitation and emission spectra of thallos gold alongside an image of thallos gold loaded cells.

Thallos gold and thallos have comparable performance with respect to thallium binding and in an inward-rectifying potassium channel assay.

Data demonstrating that ION's Brilliant thallium gold assay is less perturbed by green fluorescent compounds than thallos.

hERG assay inhibition data demonstrated using ION's Brilliant thallium gold assay for voltage-gated potassium channels.

In multi-well, plate-based formats, the Brilliant Thallium Gold Assay can be used to discover and characterize the effects of many tens-of-thousands of compounds and environmental factors on effectors of Tl+ flux. ION Brilliant Thallium Gold Flex provides all the reagents necessary for use as a washed or no-wash assay with adherent or non-adherent cells. The optional use of a probenecid solution and an extracellular background masking solution offers the ultimate in compatibility for cells types which are difficult to load with fluorescent Tl+ indicators (e.g. Chinese Hamster Ovary, CHO cells) and when performing assays in complete, serum-containing cell culture medium is desired.

Brilliant Thallium Gold

Specifications

Product Description

Documentation

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