Ion channels are essential membrane-bound proteins that control the movement of ions, such as sodium, potassium, calcium, and chloride, across cell membranes and are responsible for the regulation of numerous fundamental physiological processes. In pharmacology, ion channels serve as targets for a wide range of medical conditions, including cardiovascular disorders, neurological conditions, and pain management. Moreover, mutations that affect ion channel activity can lead to channelopathies like long QT syndrome, epilepsy, or cystic fibrosis. ION Biosciences was founded to provide better tools for studying ion channels, such as fluorescent ion indicators, in order to illuminate their roles in cell biology and uncover new modulators for these important membrane proteins. Put our expertise to work and leverage our capabilities to your organization’s benefit.
A stable HEK cell line overexpressing GIRK potassium channels for studying Kir3.1/3.2 pharmacology and Gi/o GPCRs. Be sure to check out our Gi/o GPCR-GIRK Thallium Flux Assay to discover modulators of GIRK potassium channels.
GO TO PRODUCT
Our CHO-K1 Kv11.1 (hERG) Recombinant Cell Line is a high-performance, stably expressing cell for cardiotoxicity screening and hERG drug discovery. Validated using fluorescence-based assays, like Brilliant Thallium Assay, and Automated Patch Clamp (APC) platforms, including the SyncroPatch 384, this essential cell line provides complete coverage for your hERG screening needs.
hERG channels (Kv11.1, KCNH2) are essential for cardiac repolarization, and their inhibition is a primary concern in drug safety assessment due to the risk of long QT syndrome and potential fatal arrhythmias. Given the FDA’s stringent CiPA (Comprehensive in Vitro Proarrhythmia Assay) guidelines, rigorous hERG screening is a critical step in drug development to identify off-target cardiac effects.
Be sure to check out our Brilliant Thallium Assay for a no-wash, high throughput formatted kit, suitable for voltage-gated potassium channels.
GO TO PRODUCT
Don’t see a cell line expressing your target of interest available, contact us today and our Services team can custom engineer a functional cell line for you.
Showing 1 - 2 out of 2
Page 1 out of 1
| Image | Products | Excitation | Emission | Kd | Price | Quantity | Action |
|---|---|---|---|---|---|---|---|
 |
CHO K1 Kv11.1 (hERG) Recombinant cell line
A stable CHO cell line overexpressing hERG potassium channels for studying Kv11.1 pharmacology and safety screening.
Be sure to check out our Brilliant Thallium Assay for a no-wash, high throughput formatted kit, suitable for voltage-gated potassium channels. |
|
|
|
$2,700.00
|
|
|
|
|
HEK293 - huKir3.1/3.2 cell line
A stable HEK cell line overexpressing GIRK potassium channels for studying Kir3.1/3.2 pharmacology and Gi/o GPCRs.
Be sure to check out our Gi/o GPCR-GIRK Thallium Flux Assay to discover modulators of GIRK potassium channels. |
|
|
|
$10,995.00
|
|
