$31,195.00
HEK293T GlyT1 (SLC6A9) Recombinant Cell Line is a stable, recombinant HEK293T cell line expressing GlyT1 (SLC6A9), validated using glycine uptake assays and suitable for identifying modulators of human GlyT1 activity.
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Size: 2 x 10⁶M cells
Cells/vial: 2 x 10⁶
Mycoplasma test: Pass
Species: Human
Guaranteed performance: > 10 passages
Sodium-dependent glycine transporter 1 (GlyT1, encoded by SLC6A9) is a transmembrane transporter responsible for the reuptake of glycine, the major inhibitory neurotransmitter in the central nervous system. GlyT1 is a member of the SLC6 family of sodium- and chloride-dependent neurotransmitter transporters and operates by coupling glycine transport with the co-transport of sodium and chloride ions across the plasma membrane. The transporter plays a key role in regulating extracellular glycine concentrations, particularly in glycinergic synapses and in modulating N-methyl-D-aspartate (NMDA) receptor activity through glycine clearance.
The human genome encodes two primary glycine transporters—GlyT1 (SLC6A9) and GlyT2 (SLC6A5)—with distinct expression patterns and physiological functions. Human GlyT1 is predominantly expressed in glial cells throughout the brain and spinal cord and is essential for maintaining glycine homeostasis in excitatory synapses. Dysregulation of GlyT1 function has been implicated in various neurological and psychiatric disorders, including schizophrenia, epilepsy, and cognitive dysfunction. As such, GlyT1 is a promising pharmacological target for the development of novel therapeutics aimed at modulating glycinergic and glutamatergic neurotransmission
ION Biosciences’ HEK293T GlyT1 (SLC6A9) recombinant cell line stably expresses the human glycine transporter 1 and is functionally validated using glycine uptake assays. This model is ideally suited for identifying and profiling small molecule modulators of hGlyT1 activity in both high throughput screening and detailed pharmacological studies.
