$2,700.00
A stable CHO cell line overexpressing hERG potassium channels for studying Kv11.1 pharmacology and safety screening.
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Size: 2 x 10⁶M cells
Cells/vial: 2 x 10⁶
Mycoplasma test: Pass
Species: Human
Guaranteed performance: > 10 passages
Stable cell line overexpressing the voltage-gated potassium channel, Kv11.1, for reproducible and rapid hERG assays using fluorescence-based high-throughput screening or electrophysiology. Combine these cells with our thallium flux solutions to conduct high throughput hERG assays for FDA-required safety screening or drug discovery.
Recombinant CHO-K1 KV11.1 (hERG) cell line stably expresses human hERG ion channels (KCNH2; voltage-gated potassium channel subfamily H member 2; accession number NM_000238). hERG channels are abundantly expressed in the heart and brain. In the heart, hERG channels play a crucial role in repolarization of the cardiac action potential, and inhibition of hERG current due to channelopathies or inhibitors causes long QT syndrome, a potentially fatal cardiac arrhythmia. hERG channels can be inhibited by a variety of structurally diverse compounds, thus the FDA requires that all new drug candidates are tested for off-target hERG inhibition. Besides its relevance in cardiac physiology, hERG channels are also linked to schizophrenia, tumor cell proliferation, regulation of cell migration and apoptosis.
