Go to Store

Brilliant Thallium Gold Snapshot

$211.00 – $473.00

Brilliant Thallium Gold Snapshot is a multi-instrument compatible assay solution for well plate-based, high-throughput measurements of thallium flux through potassium, sodium, and non-selective cation channels, as well as some Na+ or K+ transporters. Our patent-pending Snapshot technology generates a long-lasting signal so you can easily detect and quantify changes in ion channel or transporter activity on most fluorescence-capable instruments. The inclusion of Thallos Gold AM, our red-shifted thallium indicator, makes this kit the ideal option when using GFP-expressing cells to run potassium channel assays.

Showing 1 - 2 out of 2

Page 1 out of 1

Variation SKU Price Quantity Action
Size: pIONeer Kit - 2 plates
11021-2
$211.00
Add to cart
Size: Flex Kit - 10 plates
11021-10
$473.00
Add to cart

ION Assurance – We guarantee product quality. If you’re unsatisfied with your order, send us an email at support@ionbiosciences.com. We’ll promptly address your concern and replace, credit, or refund your items according to our ION Assurance terms and conditions.

Order in bulk and save!
Brilliant thallium gold snapshot assay kit packaging, an option for potassium channel assays, sodium channel assays, and more
SKU: 11021-1 Categories: , , Synonyms: , , , , , , , , , , ,

Specifications

Excitation:

Emission:

MW:

Filter Set:

Storage:

Product Description

ION Biosciences Brilliant Thallium Gold Snapshot Assay is a total assay solution for multi-well plate-based, high-throughput measurements of Tl+ flux through K+, Na+, non-selective cation channels, and some Na+ or K+ transporters. Our patent-pending Snapshot assay format generates a long-lasting signal so you can easily detect and quantify changes in ion channel or transporter activity on most fluorescence-capable instruments. So whether you have a FLIPR, a fluorescence microscope, a standard fluorescence plate reader, a high-content imager, or a flow cytometer – you can run functional screens on viable cells using thallium flux – enabling a whole new world of possibilities.

Snapshot Assay Principle.

Drawing that shows thallos and thallium ion loading into cells, yielding bright fluorescence
Drawing that shows thallium efflux driven by the activation of a potassium channel, resulting in a lower thallos fluorescence
Kinetic fluorescence and image data demonstrating that brilliant thallium snapshot can enable potassium channel assays on plate readers and microscopes.
hERG inhibition assay, voltage-gated potassium channel (Kv11.1) activity assay, sample data acquired using brilliant thallium gold snapshot
Brilliant Thallium Gold Snapshot simultaneously loads cells with Tl+ and Thallos Gold AM, ION’s Tl+-sensitive indicator, prior to adding an agonist/antagonist. The addition of an effector compound causes a change in fluorescence, due to Tl+ efflux or influx, that is sustained for up to 1 hr, depending on your target of interest. Brilliant Thallium Gold Snapshot has effectively identified agonists and/or antagonists of voltage-gated K+ (hERG) and Na+ (NaV) channels, inward rectifying K+ channels (GIRK1/2), and K+ and Na+ transporters (Na+/K+-ATPase) using a variety of instruments.

Documentation

protocol icon
  • Products (64)