$367.00 – $895.00
Brilliant Sodium 2 Assay is a second-generation, fluorescence-based solution designed for high-throughput screening of NaV1.X modulators. At its core is ION Natrium Green 2 AM (ING-2 AM), a membrane-permeable, sodium-sensitive, fluorescent dye that enables real-time, direct measurement of intracellular sodium channel activity. Compared to the original version, Brilliant Sodium 2 delivers larger signal amplitudes and an expanded screening window, making it well-suited for determining EC50 or IC50 values of NaV1.X activators and inhibitors.
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Brilliant Sodium 2 Assay is a second-generation, fluorescence-based solution designed for high-throughput screening of voltage-gated sodium channel (NaV1.X) modulators. Activation of NaV1.X channels by membrane depolarization or direct stimulation causes a rapid influx of sodium ions, leading to a robust fluorescence increase. This change provides a sensitive and quantitative readout of NaV1.X channel activity and pharmacological modulation.
Just like the original Brilliant Sodium Assay, this version directly measures sodium influx using ING-2 AM, a sodium-sensitive fluorescent indicator. Compared to the original version, Brilliant Sodium 2 has been reengineered to deliver:
This product is well-suited for determining EC50 or IC50 values of NaV1.X activators and inhibitors in 96- and 384-well formats for high throughput screening of voltage-gated sodium channels.
Use dual addition protocols to identify inhibitors: Compounds that inhibit NaV1.3 and NaV1.5 activity, such as tetracaine, can be identified by following a dual-addition protocol.
