Screening Services

Illuminating your next big discovery with our collection of assay services

At ION Biosciences, we specialize in the early stages of integrated drug discovery, including hit identification, hit validation, and hit-to-lead optimization, as part of our screening services portfolio. Our expertise in developing and manufacturing fluorescence-based assay technologies, combined with advanced instrumentation for even the most complex of protocols, enable high-speed, reliable data capture to accelerate your discovery journey.

We manufacture a large collection of fluorescent ion indicators and ready-to-use assay kits for discovering modulators of a large range of druggable targets, including ion channels, transporters, and GPCRs. Among these are a suite of proprietary assay technologies, including:

The only sodium-selective Sodium Channel Assay
The largest collection of Potassium Channel Assays, including a red-shifted Brilliant Thallium Gold and endpoint-compatible Brilliant Thallium Snapshot
Halotag-compatible indicators for cell-specific and organellar Ion Channel Assays
A wide array of Calcium Indicators that span the visible spectrum for multiplexing
A Gi/o GPCR Assay that measures thallium flux through GPCR-mediated GIRK channel activation
A Sodium-Dependent SLC Transporter Assay

These innovative assays showcase our commitment to advancing drug discovery and developing solutions that provide relevant, actionable insights for your pipeline. All of our assays were developed by the same experts that will support your screening service needs. Our team is supported by advanced instrumentation that can make even the most challenging of assays, routine. Led by the Panoptic from WaveFront Biosciences, a powerful fluorescence imaging plate reader (FLIPR) that is built on top of an Agilent Bravo liquid handler, that can accommodate 96-384 well plates and fluorescence or luminescence read modes. Panoptic is equipped with:

8 available bays for tip boxes, compound plates, and more to enable multi-addition protocols and complex liquid handling workflows - all while reading
Laser-based illumination (6 total lasers) that empowers multiplexing with minimal crosstalk between channels
Dual-excitation capabilities for optogenetic applications
A camera with acquisition rates up to 100 Hz to capture even the fastest calcium dynamics

We also have a Cytation 5, multimode plate reader and fluorescence imager, and Flexstation III, a lower throughput kinetic plate reader, to meet your assay needs.

Book a meeting with our experts to discuss your project

Whether you need a single high-throughput screening assay developed, recurring screening services, or a fully integrated solution, our team provides expert guidance, competitive pricing, and fast turnaround times to support your next breakthrough. Partner with us to discover a brighter future—contact our experts today.

Explore our range of screening assays

GPCR Assay Services

View our collection of functional GPCR assays for Gq, Gi, and Gs GPCRs to uncover agonists, allosteric modulators, and biased agonism

Ion Channel Assay Services

Potassium channel assays, sodium channel assays, and calcium channel assays for cardiotoxicity profiling and hit identification

SLC Transporter Assay Services

Proprietary assays to identify modulators of SLC transporters

Unable to find exactly what you are looking for?

We can build a solution just for you. Discover our Assay Development Services
and reach out to a member of our team to find out how we can help!

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