From concept to completion — assay development made simple
At ION Biosciences, we specialize in assay development as demonstrated by our history of commercializing proprietary assays for ion channels, transporters, and GPCRs. Our expertise in developing and manufacturing fluorescence-based assay technologies and stable cell lines, combined with advanced instrumentation for even the most complex of protocols, facilitate high-speed, reliable data capture to enable your next discoveries. From start to finish, our team is prepared to deliver the tools you need to achieve your goals.
What sets us apart is that we manufacture a large collection of fluorescent ion indicators and ready-to-use assay kits for discovering modulators across a broad swath of druggable targets, including ion channels, transporters, and GPCRs. Among these are a suite of proprietary technologies, including:
The only sodium-selective Sodium Channel Assay
The largest collection of Potassium Channel Assays, including our Brilliant Potassium Assays and endpoint-compatible Brilliant Thallium Snapshot Assays
A Sodium-Dependent SLC Transporter Assay with validated SLC6 expressing cell lines
Halotag-compatible indicators that enable organellar
Ion Channel Assays
A wide array of Calcium Indicators that span the visible spectrum for multiplexing, and
A Gi/o GPCR Assay that measures thallium flux through GPCR-mediated GIRK channel activation
These innovative assays showcase our commitment to advancing drug discovery and developing solutions that provide relevant, actionable insights for your pipeline. All of our assays were developed by the same experts that will support your assay development projects.
Our team is supported by advanced instrumentation that can make even the most challenging of assays, routine. Led by the Panoptic from WaveFront Biosciences, a powerful fluorescence imaging plate reader (FLIPR) that is built on top of an Agilent Bravo liquid handler, that can accommodate 96-384 well plates and fluorescence or luminescence read modes. Panoptic is equipped with:
HTS instrument inside look
We also have a Cytation 5, multimode plate reader and fluorescence imager, and Flexstation III, a lower throughput kinetic plate reader, to meet your assay needs.
Whether you need a specialized high-throughput screening assay developed, stable cell lines expressing your protein or interest, or a fully integrated solution, our team provides expert guidance, competitive pricing, and flexible technology transfer terms to support your next breakthrough. Partner with us to discover a brighter future—contact our experts today.
From vector design to a fully functional monoclonal population, our team can deliver an assay ready cell line.
We can leverage our comprehensive collection of advanced tools and assays to build an assay for your target of interest.
Signalling can be complex, which is why we have ways to measure multiple readouts within a single well.
Our Halotag collection of indicators enables us to investigate ion transport across select intracellular membranes.
Powered by our Wavefront Panoptic, washout assays, dual or triple additions, and antagonism dynamics can be explored with ease.