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SPECIFICATIONS
PRODUCT DESCRIPTION
DOCUMENTATION
REFERENCES

Fura-2 LR (leakage resistant) AM packaging with calcium (Ca2+) ion sticker, transparent background

Fura-2 LR (leakage resistant) AM packaging, transparent background

Fura-2 LR AM

$78.00 – $173.00

Leakage-resistant, ratiometric calcium (Ca²⁺) indicator, membrane permeable

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SPECIFICATIONS

Excitation:

340

380 nm

Emission:

505 nm

Kd:

145 nM

MW:

1132

Solubility:

DMSO

Purity:

>95%

Synonyms: Fura-2 Leakage Resistant, Fura-PE3

Product code: 1mg: 1061B/ 20 x 50ug: 1061E

product description

Fura-2 LR AM (leakage resistant), a ratiometric calcium indicator, banner highlighting it's use in imaging applications.

UV-excitable, ratiometric green indicator for intracellular calcium (Ca²⁺) measurements with longer cellular retention compared to Fura-2 AM and similar spectral properties. Ex/Em: 340/505 nm can be used to measure Ca²⁺-bound Fura-2, and Ex/Em: 380/505 nm can be used to detect Ca²⁺-free Fura-2. Ratiometry is optimal for imaging applications where quantification of intracellular Ca²⁺ concentrations is desired, and reduces effects of photobleaching, heterogenous dye loading, and variable cell morphology.

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documentation

coa

References

Balboa, D., Barsby, T., Lithovius, V., Saarimäki-Vire, J., Omar-Hmeadi, M., Dyachok, O., … & Otonkoski, T. (2022). Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells. Nature Biotechnology, 1-14.

Barbeau, Solène et al. “Cell Confluence Modulates TRPV4 Channel Activity in Response to Hypoxia.” Biomolecules vol. 12,7 954. 7 Jul. 2022

Vorndran C, Minta A, Poenie M. New fluorescent calcium indicators designed for cytosolic retention or measuring calcium near membranes. Biophys J. 1995 Nov;69(5):2112-24. doi: 10.1016/S0006-3495(95)80082-2

Hashitani H, Yanai Y, Suzuki H. Role of interstitial cells and gap junctions in the transmission of spontaneous Ca2+ signals in detrusor smooth muscles of the guinea-pig urinary bladder. J Physiol. 2004 Sep 1;559(Pt 2):567-81. doi: 10.1113/jphysiol.2004.065136

Groten CJ, Rebane JT, Hodgson HM, Chauhan AK, Blohm G, Magoski NS. Ca2+ removal by the plasma membrane Ca2+-ATPase influences the contribution of mitochondria to activity-dependent Ca2+ dynamics in Aplysia neuroendocrine cells. J Neurophysiol. 2016 Jun 1;115(5):2615-34. doi: 10.1152/jn.00494.2015.

Kikuta S, Iguchi Y, Kakizaki T, Kobayashi K, Yanagawa Y, Takada M, Osanai M. Store-Operated Calcium Channels Are Involved in Spontaneous Slow Calcium Oscillations in Striatal Neurons. Front Cell Neurosci. 2019. 17;13:547.

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