SPECIFICATIONS
Excitation:
530 nm 
Emission:
550 nm 
MW:
826 g/mol
Compatible instruments:
Fluorescence Microscope
Plate Reader
Flow Cytometer
HCS Instrument
HTS Instrument
Product code: 11021-10
product description
ION Biosciences Brilliant Thallium Gold Snapshot Assay is a total assay solution for multi-well plate-based, high-throughput measurements of Tl+ flux through K+, Na+, non-selective cation channels, and some Na+ or K+ transporters. Our patent-pending Snapshot assay format generates a long-lasting signal so you can easily detect and quantify changes in ion channel or transporter activity on most fluorescence-capable instruments. So whether you have a FLIPR, a fluorescence microscope, a standard fluorescence plate reader, a high-content imager, or a flow cytometer – you can run functional screens on viable cells using thallium flux – enabling a whole new world of possibilities.
Brilliant Thallium Gold Snapshot simultaneously loads cells with Tl+ and Thallos Gold AM, ION’s Tl+-sensitive indicator, prior to adding an agonist/antagonist. The addition of an effector compound causes a change in fluorescence, due to Tl+ efflux or influx, that is sustained for up to 1 hr, depending on your target of interest. Brilliant Thallium Gold Snapshot has effectively identified agonists and/or antagonists of voltage-gated K+ (hERG) and Na+ (NaV) channels, inward rectifying K+ channels (GIRK1/2), and K+ and Na+ transporters (Na+/K+-ATPase) using a variety of instruments.
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