Brilliant Thallium Gold Snapshot

$211.00$473.00

Brilliant Thallium Gold Snapshot is a multi-instrument compatible assay solution for well plate-based, high-throughput measurements of thallium flux through potassium, sodium, and non-selective cation channels, as well as some Na+ or K+ transporters. Our patent-pending Snapshot technology generates a long-lasting signal so you can easily detect and quantify changes in ion channel or transporter activity on most fluorescence-capable instruments. The inclusion of Thallos Gold AM, our red-shifted thallium indicator, makes this kit the ideal option when using GFP-expressing cells to run potassium channel assays. 

SPECIFICATIONS

Excitation:

530 nm

Emission:

550 nm

MW:

826 g/mol

Compatible instruments:

Fluorescence Microscope

well plate icon for plate reader compatibility

Plate Reader

flow cytometry icon

Flow Cytometer

HCS (high content screening) instrument logo

HCS Instrument

HTS (high throughput screening) instrument logo

HTS Instrument

Product code: 11021-10

product description

ION Biosciences Brilliant Thallium Gold Snapshot Assay is a total assay solution for multi-well plate-based, high-throughput measurements of Tl+ flux through K+, Na+, non-selective cation channels, and some Na+ or K+ transporters. Our patent-pending Snapshot assay format generates a long-lasting signal so you can easily detect and quantify changes in ion channel or transporter activity on most fluorescence-capable instruments. So whether you have a FLIPR, a fluorescence microscope, a standard fluorescence plate reader, a high-content imager, or a flow cytometer – you can run functional screens on viable cells using thallium flux – enabling a whole new world of possibilities.

Brilliant Thallium Gold Snapshot simultaneously loads cells with Tl+ and Thallos Gold AM, ION’s Tl+-sensitive indicator, prior to adding an agonist/antagonist. The addition of an effector compound causes a change in fluorescence, due to Tl+ efflux or influx, that is sustained for up to 1 hr, depending on your target of interest. Brilliant Thallium Gold Snapshot has effectively identified agonists and/or antagonists of voltage-gated K+ (hERG) and Na+ (NaV) channels, inward rectifying K+ channels (GIRK1/2), and K+ and Na+ transporters (Na+/K+-ATPase) using a variety of instruments.

documentation

0