Discover ION Biosciences’ Gi/o GPCR-GIRK thallium flux assay for real-time GPCR readouts through a native coupling mechanism to GIRK potassium channels. Unlock high-throughput screening with flexibility to insert any Gi GPCR transiently and uncover new hits. Some validated targets include dopamine, serotonin, muscarinic, and opioid receptors.