Custom Synthesis

Custom chemistry solutions to illuminate your next big breakthrough

ION Biosciences was initially founded to synthesize highly differentiated ion indicators of the highest quality, and as we’ve grown into other fields we’ve never left our roots. Our organic chemists still synthesize products in-house to support our ever growing product catalog as well as our assay development and screening services, keeping ION Biosciences at the forefront of developing industry trends. By combining all of these services at one company, we’ve created an exceptional ability to rapidly develop and synthesize fluorescent probes, conjugatable ion indicators and many leading advances in the field of fluorescence-based assays.

By offering custom chemistry services while also developing world class fluorescent indicators, ION Biosciences maintains an overwhelming advantage over our competitors who must outsource important aspects of the development process. By leveraging our ability to develop a wide variety of assays, modify cellular expressions and conduct complex screening protocols, ION Biosciences can deliver a custom fluorescent probe or conjugated ion indicator within your project timeline and budget. Some of our advances include:

Alt-text: This graph shows the relative fluorescence vs. wavelength of 3 fluorescent calcium indicators made by Ion Biosciences

  • Synthesis of dyes that span the visible spectrum

  • Fluorescent indicators that can detect select ions with a range of affinity and responsiveness

  • Self-labeling protein tags, like Halotag-ligands, for cell-specific and organellar ion channel assays, similar to Thallos-Gold HTL

  • Ion indicators functionalized with conjugatable moieties including for click chemistry or bioconjugation

Our proprietary fluorescent probes and conjugatable indicators highlight our teams ability to deliver novel, tailored chemistry solutions. Let ION Biosciences your next big discovery! Our custom synthesis team is supported by advanced degrees, modern synthetic methodologies and advanced instrumental techniques. When you trust ION Biosciences with your custom chemistry, you leverage our ability to synthesize at production scales, develop robust intellectual property and deliver high quality results in the timeframe of your choosing and within your budget constraints. To ensure we’re good stewards of our customer’s time, we utilize our in-house analytical instruments for instantaneous structural elucidation and rapid verification of synthetic progress. Institutional equipment includes:
An NMR spectrum of the Fluo-4 AM fluorescent calcium indicator.
  • Agilent Infinity II Liquid Chromatograph/Mass Spectrograph (LCMS)
  • Bruker Avance 400MHz NMR
  • ECOM Preparative-Flash Liquid Chromatograph
  • Labconco Lyophilizers
Book a meeting with our experts to discuss your project

We are experts at all aspects of organic synthesis including integrating crown ethers and complexing/chelating ring systems, hindered couplings and appending functional tags or ligands. Whether you need a single molecule or a series, from milligrams to kilograms, our team provides expert insights, competitive pricing and fast turnaround times to support your next breakthrough. Partner with us to discover a brighter future—contact our experts today.

Explore our custom synthesis capabilities

Images of fluorescent cells showing calcium mobilization with Ion Biosciences’ Fluo-Gold

Custom Fluorescent Probes

Build custom probes off a variety of fluorescent scaffolds such as Fluorescein, Rhodamine, BODIPY, and Coumarins
Halotag expressing cells fluorescing with intracellular Thallos HTL dye from Ion Biosciences

Conjugatable Ion Indicators

Conjugate to proteins, ligands or inorganic substrates to detect a variety of ions or cellular events
A picture of cells stained magenta by loading with a proprietary fluorescent dye.

Contract Chemistry

From one-time projects to recurring production cycles, our capacity to deliver is unparalleled

Unable to find exactly what you are looking for?

We can synthesize a solution just for you. Reach out to a member of our team to find out how we can help!
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