Solute carrier transporters (SLC) facilitate uptake and efflux of a wide range of ions, metabolites and nutrients critical for maintaining cellular homeostasis, by coupling transport mechanisms to ion gradients.
These SLC transporters include SLC1, SLC5, SLC6, SLC8, SLC9, SLC20, SLC23, and SLC24 to name a few examples. They are known to shuttle nutrients, amino acids, neurotransmitters, ions and more across cellular membranes, and are being therapeutically targeted for conditions ranging from psychiatric disorders to kidney function.
ION Biosciences’ Sodium-dependent SLC Transporter Assay utilizes ION Natrium Green 2 (ING-2 AM), a sodium-sensitive fluorescent indicator, to detect solute carrier (SLC) transporter mediated sodium influx. This assay kit provides a highly-sensitive, robust, and high-throughput method to measure sodium-dependent SLC transporter activity.
(EX 525 nm, EM 545 nm) ION’s Sodium-dependent SLC Transporter Assay detects SLC transporter activity of SLCs that cotransport sodium, such as the SLC6 transporter family. This assay is ideal for hit finding and lead optimization applications in drug discovery, and can be used to discover substrates, potentiators, and inhibitors of sodium-dependent SLC transporters
The SLC12 family facilitates the movement of ions across membranes for cell volume maintenance, salt transport, and neurotransmission regulation. SLC12 transporters are electroneutral, and include NKCC1/2 and KCC1/2/3/4.
Thallium flux assays have been developed to screen for potentiators and inhibitors of some members of this family. We manufacture a collection of thallium flux assays that could be used to identify modulators of SLC12 transporters.
(EX 490 nm, EM 515 nm) High-throughput, no wash thallium flux assay. An optimal solution for measuring the activity of potassium channels and transporters, as well as sodium channels, non-selective cation channels, and Gi/o GPCRs.
(EX 530 nm, EM 550 nm) Brilliant Thallium Gold includes Thallos Gold – ION’s gold fluorescent thallium (Tl+) indicator. Red-shifted excitation and emission enable multiplexing with GFP-expressing cells or other green fluorescent indicators. Useful for fluorescence-based potassium channel assays and for studying a wide variety of monovalent cation channels (sodium channels), transporters, and GPCRs.
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Sodium-Dependent SLC Transporter Assay
ION’s Sodium-dependent SLC Transporter Assay detects SLC transporter activity of SLCs that co-transport sodium, such as the SLC6 transporter family. This assay is ideal for hit finding and lead optimization applications in drug discovery, and can be used to discover substrates, potentiators, and inhibitors of sodium-dependent SLC transporters. |
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$895.00
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Brilliant Thallium Gold
A potassium channel assay, and so much more. Brilliant Thallium Gold includes Thallos Gold - ION’s gold fluorescent (Ex/Em = 528/552 nm) thallium (Tl+) indicator. Red-shifted excitation and emission enable multiplexing with GFP-expressing cells or other green fluorescent indicators. Useful for fluorescence-based potassium (K+) channel assays and for studying a wide variety of monovalent cation channels (sodium channels), transporters, and GPCRs. |
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$221.00 – $496.00
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Brilliant Thallium
A potassium channel assay, and so much more. ION’s high-throughput, no wash thallium (Tl⁺) flux assay is an optimal solution for measuring the activity of potassium (K⁺), sodium (Na⁺), and non-selective cation channels and their effectors including transporters and GPCRs. |
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$221.00 – $3,776.00
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