Off-the-shelf cell lines for your drug discovery campaign
Great assays begin with cells that are designed for your end use. That’s why all of our cells have been carefully selected based on functional performance with a pharmacologically relevant, fluorescence-based assay – making them ideally suited for high throughput ion channel and GPCR screening applications.
A human cell line stably expressing a high-conductance GIRK channel for thallium flux assays. Can couple to transiently or stably expressed Gi/o GPCRs for a direct readout of GPCR agonism.
A stable CHO cell line overexpressing hERG potassium channels for studying Kv11.1 pharmacology and safety screening.
Coming soon!
A stable, recombinant HEK293T cell line expressing GlyT1 (SLC6A9), validated using glycine uptake assays and suitable for identifying modulators of human GlyT1 activity.
HEK293T GAT1 (SLC6A1) recombinant cell line stably expresses the human GABA transporter and provides a validated in vitro model for studying GAT1 function and pharmacology. This cell line is optimized for high-throughput screening of GAT1 inhibitors or substrates, functional uptake assays, and kinetic studies of transporter activity. Its strong, reproducible sodium-dependent GABA uptake and compatibility with fluorescence-based assays make it an ideal platform for advancing drug discovery efforts targeting GABAergic pathways in CNS disease.
Check out our Sodium-dependent SLC Transporter Assay for a highly-sensitive, robust, and high-throughput method to measure sodium-dependent SLC transporter activity.
Don’t see a cell line expressing your target of interest available, contact us today and our Services team can custom engineer a functional cell line for you.
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CHO K1 Kv11.1 (hERG) Recombinant cell line
A stable CHO cell line overexpressing hERG potassium channels for studying Kv11.1 pharmacology and safety screening.
Be sure to check out our Brilliant Thallium Assay for a no-wash, high throughput formatted kit, suitable for voltage-gated potassium channels. |
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$2,700.00
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HEK293T GAT1 (SLC6A1) Cell Line
HEK293T GAT1 (SLC6A1) recombinant cell line stably expresses the human GABA transporter and provides a validated in vitro model for studying GAT1 function and pharmacology. This cell line is optimized for high-throughput screening of GAT1 inhibitors or substrates, functional uptake assays, and kinetic studies of transporter activity. Its strong, reproducible sodium-dependent GABA uptake and compatibility with fluorescence-based assays make it an ideal platform for advancing drug discovery efforts targeting GABAergic pathways in CNS disease.
Check out our Sodium-dependent SLC Transporter Assay for a highly-sensitive, robust, and high-throughput method to measure sodium-dependent SLC transporter activity. |
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$31,195.00
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HEK293 Kv11.1 (hERG) Cell Line
ION Biosciences' HEK293 KV11.1 (hERG) recombinant cell line stably expresses human KCNH2 and provides a robust, well-validated model for investigating KV11.1 channel function. This cell line is ideally suited for high-throughput screening of channel modulators, safety pharmacology assays, and mechanistic studies aimed at discovering novel inhibitors or activators of KV11.1. With excellent reproducibility and functional expression, these cells facilitate efficient evaluation of compound effects on KV11.1 currents using fluorescence-based assays. |
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HEK293 - huKir3.1/3.2 cell line
A stable HEK cell line overexpressing GIRK potassium channels for studying Kir3.1/3.2 pharmacology and Gi/o GPCRs.
Be sure to check out our Gi/o GPCR-GIRK Thallium Flux Assay to discover modulators of GIRK potassium channels. |
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$10,995.00
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HEK293T GlyT1 (SLC6A9) Recombinant Cell Line
HEK293T GlyT1 (SLC6A9) Recombinant Cell Line is a stable, recombinant HEK293T cell line expressing GlyT1 (SLC6A9), validated using glycine uptake assays and suitable for identifying modulators of human GlyT1 activity.
Be sure to check out our new Sodium-dependent SLC Transporter Assay for screening SLCs that co-transport sodium. |
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$31,195.00
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