Solute Carrier (SLC) transporters are a large and diverse group of membrane-bound proteins responsible for the uptake and distribution of a wide range of substrates, including ions, nutrients, and metabolites across cellular membranes. Comprising over 400 members divided into more than 60 families, SLC transporters are essential for maintaining cellular homeostasis and responding to physiological demands. This is the second largest family of membrane proteins behind G-protein coupled receptors (GPCRs). SLCs function predominantly via facilitated diffusion or secondary active transport, distinguishing them from ATP-binding cassette (ABC) transporters which use ATP hydrolysis directly for substrate movement.
HEK293T GlyT1 (SLC6A9) Recombinant Cell Line is a stable, recombinant HEK293T cell line expressing GlyT1 (SLC6A9), validated using glycine uptake assays and suitable for identifying modulators of human GlyT1 activity.
Be sure to check out our new Sodium-dependent SLC Transporter Assay for screening SLCs that co-transport sodium.
HEK293T GAT1 (SLC6A1) recombinant cell line stably expresses the human GABA transporter and provides a validated in vitro model for studying GAT1 function and pharmacology. This cell line is optimized for high-throughput screening of GAT1 inhibitors or substrates, functional uptake assays, and kinetic studies of transporter activity. Its strong, reproducible sodium-dependent GABA uptake and compatibility with fluorescence-based assays make it an ideal platform for advancing drug discovery efforts targeting GABAergic pathways in CNS disease.
Check out our Sodium-dependent SLC Transporter Assay for a highly-sensitive, robust, and high-throughput method to measure sodium-dependent SLC transporter activity.
Don’t see a cell line expressing your target of interest available, contact us today and our Services team can custom engineer a functional cell line for you.
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HEK293T GAT1 (SLC6A1) Cell Line
HEK293T GAT1 (SLC6A1) recombinant cell line stably expresses the human GABA transporter and provides a validated in vitro model for studying GAT1 function and pharmacology. This cell line is optimized for high-throughput screening of GAT1 inhibitors or substrates, functional uptake assays, and kinetic studies of transporter activity. Its strong, reproducible sodium-dependent GABA uptake and compatibility with fluorescence-based assays make it an ideal platform for advancing drug discovery efforts targeting GABAergic pathways in CNS disease.
Check out our Sodium-dependent SLC Transporter Assay for a highly-sensitive, robust, and high-throughput method to measure sodium-dependent SLC transporter activity. |
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HEK293T GlyT1 (SLC6A9) Recombinant Cell Line
HEK293T GlyT1 (SLC6A9) Recombinant Cell Line is a stable, recombinant HEK293T cell line expressing GlyT1 (SLC6A9), validated using glycine uptake assays and suitable for identifying modulators of human GlyT1 activity.
Be sure to check out our new Sodium-dependent SLC Transporter Assay for screening SLCs that co-transport sodium. |
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$31,195.00
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