D2 Dopamine Receptor Assay(s)

Background Information

The D2 dopamine receptor is a G protein-coupled receptor (GPCR) that is associated with Gi/o GPCRs. It plays a critical role in neurophysiology and cardiac physiology and is a potential therapeutic target for various pathologies, including epilepsy, Parkinson’s disease, Down’s syndrome, pain, and drug addiction

Family: GPCR
Protein Name: D2 Dopamine Receptor
Gene Name: DRD2

Organism : Human
Therapeutic Area: CNS

Assay Information

Validated Assay(s): cAMP, Gi/o GPCR-GIRK Thallium Flux Assay, Thallium-free GIRK Potassium Channel Assay
Assay type: Cell-based
Method: Fluorescence

Instrumentation: FLIPR, Panoptic, Flexstation
Plate Format: 96- or 384-well
Expression: Transient
Cell type: HEK293T or HEK293 GIRK

Testing Information

Functional Mode(s): Agonist, Antagonist, Allosteric modulators
Reference compound(s): Dopamine

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